Infertility in Murine Acute Trypanosoma cruzi Infection Is Associated with Inhibition of Pre-Implantation Embryo Development
نویسندگان
چکیده
منابع مشابه
Trypanosoma cruzi: paninfectivity of CL strain during murine acute infection.
A systematic study of the distribution of intracellular parasites in the organs and tissues of mice acutely infected (15 days) with the CL strain of Trypanosoma cruzi was performed. Almost all tissues and organs were parasitized with different intensities, including several epithelial cell types. In addition to striated, cardiac, and smooth muscles a very high parasitism of fat cells, pancreas,...
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Understanding human pre-implantation development has important implications for assisted reproductive technology (ART) and for human embryonic stem cell (hESC)-based therapies. Owing to limited resources, the cellular and molecular mechanisms governing this early stage of human development are poorly understood. Nonetheless, recent advances in non-invasive imaging techniques and molecular and g...
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Background: Hyaluronan (HA) is a structural component of extracellular matrix synthesised by HA synthases HAS1-3, which produce HA of different molecular sizes with distinct biological functions associated with reproductive processes. Hyaluronidase (HYAL) cleaves the HA into biologically active small fragments which are known to regulate cell proliferation through CD44 receptor signaling. HA is...
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Introduction: Women with poorly controlled insulin-dependent diabetes mellitus (IDDM) have a much higher incidence of early pregnancy complications, these include spontaneous miscarriages, early growth delay, and congenital malformations. Most of the investigations have been devoted to the early post implantation and organogenesis period of pregnancy. In this research we studied the hyperglycem...
متن کاملEfficacy of voriconazole in a murine model of acute Trypanosoma cruzi infection.
OBJECTIVES Antifungal triazole derivatives have been studied as possible alternatives for the treatment of Chagas' disease. Voriconazole has demonstrated in vitro activity against Trypanosoma cruzi, but its efficacy in vivo has not yet been tested. We aimed to determine the effect of voriconazole in a murine model of acute T. cruzi infection. METHODS Treatment efficacy was evaluated by compar...
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ژورنال
عنوان ژورنال: The American Journal of Pathology
سال: 2006
ISSN: 0002-9440
DOI: 10.2353/ajpath.2006.060309